Novel product and process for t lymphocyte veto

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) A61K 47/48 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 14/73 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2251819

The present invention relates to a product and process for suppressing an immune response using a T lymphocyte veto molecule capable of blocking cell surface molecules responsible for T cell activation. Disclosed is a CD4 or CD2 molecule, associated with an immunoglobulin molecule capable of binding to a major histocompatibility antigen. Also disclosed is a method to produce a T lymphocyte veto molecule, a therapeutic composition comprising a T lymphocyte veto molecule and methods to use T lymphocyte veto molecules in therapeutic processes requiring suppression of an immune response.

La présente invention concerne un produit et un procédé pour supprimer une réaction immunitaire à l'aide d'une molécule véto des lymphocytes T capable de bloquer les molécules de surface cellulaire responsables de l'activation des cellules T. L'invention concerne également une molécule CD4 ou CD2 associée à une molécule d'immunoglobuline capable de se fixer sur un antigène du complexe majeur d'histocompatibilité. L'invention concerne par ailleurs un procédé pour produire une molécule véto des lymphocytes T, une composition thérapeutique comprenant celle-ci, ainsi que des méthodes pour utiliser des molécules véto des lymphocytes T dans des processus thérapeutiques nécessitant la suppression d'une réaction immunitaire.

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