Certain fused pyrrolecarboxamides as gaba brain receptor...

Details Certain fused pyrrolecarboxamides as gaba brain receptor... Certain fused pyrrolecarboxamides as gaba brain receptor...

C - Chemistry, Metallurgy

07

D

C07D 209/42 (2006.01) C07D 209/52 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2249562

Diclosed are compounds of formula (I), or the pharmaceutically acceptable non-toxic salts thereof, wherein W represents substituted or unsubstituted phenyl; T is hydrogen, halogen, hydroxyl, amino or alkyl; X is hydrogen, hydroxy, or lower alkyl; m is 0, 1, or 2; n is 0, 1, or 2; and R3 and R4 represent substituted or unsubstituted organic residues. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.

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