Phenol derivatives and their use to modulate pkb activity

Details Phenol derivatives and their use to modulate pkb activity Phenol derivatives and their use to modulate pkb activity

A - Human Necessities

61

K

A61K 31/05 (2006.01) A61K 31/085 (2006.01) A61K 31/137 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07C 39/00 (2006.01) C07C 43/00 (2006.01) C07C 59/00 (2006.01) C07C 213/00 (2006.01)

Patent

CA 2601503

The present invention provides the use of a compound of the Formula: (I) wherein R1 is C1-5 alkoxy, OCOC1-3Alkyl, O(CH2)2O(CH2)2O(CH2)2OMe, O(CH2)2O(CH2)2O(CH2)2OH or OH; R2 is H, (CH2)nOH, OCH3, Hal or (II) or (III) R3 is H or (CH2)nOH; and R4 is C1-6 alkyl, optionally substituted by one or more of Hal, OH, COCH3, NH2, NHCH3, NHMe, NMe2, OCOCH3, CO2H or esters or amides thereof where n is 1-5; and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in modulating PKB activity.

L'invention concerne l'utilisation d'un composé de formule (I). Dans cette formule R1 désigne alkoxy C1-5, alkyl OCOC1-3, O(CH2)2O(CH2)2O(CH2)2OMe, O(CH2)2O(CH2)2O(CH2)2OH ou OH; R2 désigne H, (CH2)nOH, OCH3, Hal ou (II) ou (III) ; R3 désigne H ou (CH2)nOH; et R4 désigne alkyle C1-6, éventuellement substitué par au moins: Hal, OH, COCH3, NH2, NHCH3, NHMe, NMe2, OCOCH3, CO2H ou des esters, ou des amides de ceux-ci et n est compris entre 1 et 5. L'invention concerne également des sels pharmaceutiquement acceptables du composé susmentionné, et la fabrication d'un médicament comportant le composé de l'invention ou ses sels, ledit médicament pouvant être utilisé pour moduler l'activité de PKB.

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