C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 37/04 (2006.01) C12P 21/08 (2006.01) C12N 5/24 (2006.01)
Patent
CA 2309602
The methods and compositions of the present invention are directed to enhancing an immune response and increasing vaccine efficacy through the simultaneous or sequential targeting of specific immune system components. More particularly, specific immune components, such as macrophages, dentritic cells, B cells and T cells, are individually activated by component-specific immunostimulating agents. One such component-specific immunostimulating agent is an antigen-specific, species-specific monoclonal antibody. The invention is also directed to a method for the in vitro production of the antigen-specific, species-specific monoclonal antibodies which relies upon the in vitro conversion of blood-borne immune cells, such as macrophages and lymphocytes. Vaccine efficacy is enhanced by the administration of compositions containing component-specific immunostimulating agents and other elements, such as antigens or carrier particles, such as colloidal methods, such as gold.
Ces techniques, ainsi que les compositions afférentes, visent au renforcement d'une réponse immunitaire et à l'augmentation de l'efficacité vaccinale et ce, par ciblage simultané ou successif de composants spécifiques de système immunitaire. Plus précisément, on active individuellement des composants immuns spécifiques, par exemple des macrophages, des cellules dendritiques, des lymphocytes B et T, à l'aide d'agents immuno-stimulateurs spécifiques du composant. Cet agent immuno-stimulateur spécifique du composant est un anticorps monoclonal spécifique d'un antigène et d'une espèce. Cette invention concerne également une technique de production in vitro de ces anticorps monoclonaux reposant sur la conversion in vitro de cellules immunitaires d'origine sanguine, notamment des macrophages et des lymphocytes. On renforce l'efficacité vaccinale en administrant des compositions contenant les agents immuno-stimulateurs susmentionnés et d'autres éléments, notamment des antigènes ou des particules vectrices, de l'or par exemple, dans le cadre de méthodes utilisant des colloïdes.
Paciotti Giulio F.
Tamarkin Lawrence
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cytimmune Sciences Inc.
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