Prevention and treatment of ischemia-reperfusion and...

Details Prevention and treatment of ischemia-reperfusion and... Prevention and treatment of ischemia-reperfusion and...

A - Human Necessities

61

K

A61K 31/675 (2006.01) A61K 31/00 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2186915

Methods of preventing or treating ischemia-reperfusion injury in an organ by administration of a composition containing a selective A1 adenosine receptor antagonist and/or a P2x purinoceptor antagonist are provided. Method of preventing or treating endotoxin-related lung injury by administration of a composition containing a selective A1 adenosine receptor antagonist and/or a P2x purinoceptor antagonist are also provided.

Prévention et traitement des lésions résultant de l'ischémie consécutive à une reperfusion dans un organe par administration d'une composition renfermant un antagoniste de récepteur d'adénosine A¿1? sélectif et/ou un antagoniste de purinorécepteur P¿2x?. L'invention porte également sur des méthodes de prévention ou de traitement des lésions pulmonaires liées à l'endotoxine par administration d'une composition renfermant un antagoniste de récepteur d'adénosine A¿1? sélectif et/ou un antagoniste de purinorécepteur P¿2x?.

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