Surfactants as malarial chloroquine resistance reversal agents

Details Surfactants as malarial chloroquine resistance reversal agents Surfactants as malarial chloroquine resistance reversal agents

A - Human Necessities

61

K

A61K 47/34 (2006.01) A61K 31/09 (2006.01) A61K 31/4706 (2006.01) A61P 33/06 (2006.01)

Patent

CA 2392741

According to the first aspect of the invention, a composition for reversing malarial resistance to quinolines is disclosed. The composition includes a surfactant, such as nonylphenolethoxylate (NPE) in an admixture with a pharmaceutically acceptable carrier, excipient, or diluent. According to a second aspect of the invention, a composition for the prevention or treatment of malaria is provided. The composition comprises a pharmaceutically effective amount of a quinoline in combination with a surfactant, such as NPE, for reversing malarial resistance to quinolines. According to a third aspect of the invention, a method of preventing or treating malaria in a person is provided. The method comprises administering to a patient in need thereof one or both of the compositions described above.

Dans un premier aspect, l'invention concerne une composition destinée à inverser la résistance paludéenne aux quinolines. Cette composition comprend un tensioactif, tel que le nonylphénoléthoxylate (NPE) dans un mélange additionnel avec un support, un excipient ou un diluant pharmaceutiquement acceptable. Dans un second aspect, l'invention concerne une composition destinée à la prévention ou au traitement de la malaria. Cette composition comprend une quantité pharmaceutiquement efficace d'une quinoline combinée à un tensioactif, tel que NPE, afin d'inverser la résistance paludéenne aux quinolines. Dans un troisième aspect, l'invention concerne une méthode de prévention ou de traitement de la malaria sur un patient. Cette méthode consiste à administrer au patient une ou plusieurs des compositions décrites ci-dessus.

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