Treatment regimen for administration of...

A - Human Necessities – 61 – K

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A61K 31/198 (2006.01) A61K 31/192 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2336945

Herein is disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated aqueous solution of phenylacetylglutamine and phenylacetylisoglutamine in a 4:1 ratio, at an infusion rate of from 100 mL/hr to 400 mL/hr. In a further embodiment, herein is also disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated aqueous solution of phenylacetate and (phenylacetylglutamine or phenylacetylisoglutamine) in a 4:1 ratio, at an infusion rate of from 100 mL/hr to 400 mL/hr. Herein are also disclosed the pharmaceutical compositions used in the above methods.

L'invention concerne un procédé relatif au traitement des maladies néoplasiques, y compris le cancer, consistant à administrer une composition pharmaceutique, laquelle comprend une solution aqueuse très concentrée de phénylacétylglutamine et de phénylacétylisoglutamine selon un rapport 4:1 et suivant une vitesse de perfusion comprise entre 100 et 400 ml/h. L'invention concerne en outre un procédé relatif au traitement des maladies néoplasiques, y compris le cancer, consistant à administrer une composition pharmaceutique, laquelle comprend une solution aqueuse très concentrée de phénylacétate et de (phénylacétylglutamine ou de phénylacétylisoglutamine) selon un rapport 4:1 et suivant une vitesse de perfusion comprise entre 100 et 400 ml/h. L'invention concerne également les compositions pharmaceutiques utilisés dans le cadre des procédés susmentionnés.

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