C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/30 (2006.01) A61K 31/4412 (2006.01) A61P 9/10 (2006.01) A61P 27/02 (2006.01)
Patent
CA 2614857
The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypyridine derivatives and salts thereof (compound 1) having antioxidant, geroprotective and anti- ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypyridine and dicarboxylic in solution of a lower alcohol at a temperature of 60-100°C with following treatment of the reaction mass with an organic solvent and maintaining for 2-5 h at 10-15 °C.
L'invention appartient au domaine de la médecine et concerne notamment de nouvelles compositions biologiquement actives, et plus particulièrement des dérivés de 2,4,6-triméthyl-3-hydroxypyrydine et ses sels (composition 1) qui possèdent une activité antioxydante, géroprotectrice et anti-ischémique. Les sels des compositions (1) sont obtenues par l'interaction des quantités équimoléculaires de 2,4,6-triméthyl-3-hydroxypyrydine avec l'acide bicarbonique dans une solution d'alcool inférieur à une température de 60 à 100 °C, suivie d'un traitement de la masse de réaction avec un solvant organique et une retenue durant 2-5 h à 10-15 °C. (formule)
Doncov Aleksandr Evgenievich
Ostrovsky Michail Arkadievich
Sipyagin Aleksey Michailovich
Smipnov Leonid Dmitrievich
Borden Ladner Gervais Llp
Marvel Lifesciences Limited
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