Hs2sts as modifiers of the p53 pathway and methods of use

Details Hs2sts as modifiers of the p53 pathway and methods of use Hs2sts as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2449267

Human HS2ST genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of HS2ST are provided.

L'invention concerne des gènes HS2ST humains identifiés comme modulateurs de la voie p53, qui sont donc des cibles thérapeutiques pour des troubles associés à une fonction p53 défectueuse. L'invention concerne également des méthodes d'identification des modulateurs de p53, ces méthodes consistant à dépister des agents qui modulent l'activité de HS2ST.

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