Use of oligonucleotide phosphorothioate for depleting...

Details Use of oligonucleotide phosphorothioate for depleting... Use of oligonucleotide phosphorothioate for depleting...

A - Human Necessities

61

K

A61K 31/70 (2006.01)

Patent

CA 2191192

Disclosed are methods of reducing the blood pressure, stimulating vasodilation, and depleting complement, in a primate. These methods involve administering an oligonucleotide to the primate, and then measuring the decrease in blood pressure or complement activity. The oligonucleotide being administered is 2 to 50 nucleotides in length and has at least one phosphorothioate internucleotide linkage.

L'invention concerne des procédés de réduction de la pression sanguine, de stimulation de la vasodilatation, et de déplétion du complément chez un primate. Ces procédés consistent à administrer un oligonucléotide au primate, et à mesurer la réduction de la pression sanguine ou de l'activité du complément. L'oligonucléotide administré présente une longueur de 2 à 50 nucléotides et au moins une liaison internucléotidique phosphorothioate.

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