Platelet-specific chimeric immunoglobulin and methods of use...

Details Platelet-specific chimeric immunoglobulin and methods of use... Platelet-specific chimeric immunoglobulin and methods of use...

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223885

Agents which selectively bind GPIIb/IIIa and the vitronectin receptor are disclosed and can be used to reduce or prevent occlusion, reocclusion (e.g, abrupt closure), stenosis and/or restenosis. In one embodiment, an immunoglobulin or immunoglobulin fragment, such as a platelet-specific chimeric immunoglobulin or fragment thereof comprising a nonhuman antigen binding region and a human constant region, is used in the method.

L'invention concerne des agents qui se lient de manière sélective à la GPIIb/IIIa et au récepteur de vitronectine et peuvent s'utiliser pour réduire ou prévenir les phénomènes d'occlusion, de réocclusion (par ex. fermeture soudaine), de sténose et/ou de récidive de sténose. Dans une variante, une immunoglobuline ou un fragment d'immunoglobuline, telle qu'une immunoglobuline chimérique spécifique des plaquettes ou un de ses fragments comprenant une région non humaine de liaison d'antigène et une région humaine constante, est utilisée dans le procédé.

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