Genetic vaccine against human immunodeficiency virus

Details Genetic vaccine against human immunodeficiency virus Genetic vaccine against human immunodeficiency virus

C - Chemistry, Metallurgy

12

N

C12N 15/48 (2006.01) A61K 31/7088 (2006.01) A61K 39/12 (2006.01) A61K 39/21 (2006.01) A61K 48/00 (2006.01) A61P 31/18 (2006.01) C07K 14/02 (2006.01) C07K 14/08 (2006.01) C07K 14/16 (2006.01) C12N 15/49 (2006.01) C12N 15/63 (2006.01) C12N 15/861 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2465037

Recombinant adenovirus and methods of administration to a host are provided for eliciting immune response of the host to human immunodeficiency virus (HIV). The recombinant adenovirus is capable of expressing multiple wild type or mutant HIV antigens such as HIV envelope proteins without the cleavage site or the cytosolic domain, structural proteins such as Gag and its proteolytical fragments in a natural, secreted or membrane-bound form, HIV enzymes such as reverse transcriptase, protease and integrase, and regulatory proteins such as Tat, Rev and Nef. Immuno-stimulators such as cytokines can also be expressed by the recombinant adenovirus to further enhance the immunogenicity of the HIV antigens.

L'invention concerne des adénovirus de recombinaison et des méthodes d'administration à un hôte permettant de déclencher une réponse immunitaire de l'hôte au virus de l'immunodéficience humaine (VIH). L'adénovirus de recombinaison peut permettre l'expression de divers antigènes mutants ou de type sauvage du VIH, tels que les protéines d'enveloppe du VIH sans le site de restriction ou sans le domaine cytosolique, des protéines structurales, telles que Gag et ses fragments protéolytiques sous une forme naturelle, sécrétée ou membranaire, des enzymes du VIH, telles que la transcriptase inverse, la protéase et l'intégrase, et des protéines régulatrices, telles que Tat, Rev et Nef. Des immunostimulateurs, tels que des cytokines peuvent être également exprimés par l'adénovirus de recombinaison afin d'augmenter un peu plus l'immunogénicité des antigènes du VIH.

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