Prostaglandin agonists and their use to treat bone disorders

Details Prostaglandin agonists and their use to treat bone disorders Prostaglandin agonists and their use to treat bone disorders

C - Chemistry, Metallurgy

07

D

C07D 213/71 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/4164 (2006.01) A61K 31/425 (2006.01) A61K 31/443 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 13/12 (2006.01) A61P 19/00 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 27/06 (2006.01) C07C 311/00 (2006.01) C07D 213/38 (2006.01) C07D 213/70 (2006.01) C07D 233/06 (2006.01) C07D 233/84 (2006.01) C07D 239/24 (2006.01) C07D 239/

Patent

CA 2305548

This invention relates to compounds of the Formula: Image or a pharmaceutically acceptable salt thereof, wherein Ar is an optionally substituted, partially saturated or fully unsaturated monocyclic or partially saturated, fully saturated or fully unsaturated bicyclic or tricyclic ring optionally having 1 or more heteroatoms or an optionally substituted heterocyclic ring; K is a bond or an optionally substituted and optionally mono unsaturated alkylene, thioalkylene, alkylenethioalkylene, alkyleneoxyalkylene or oxyalkylene; M is Ar3 or Ar3-Ar3 which may be interrupted by another group, and wherein Ar3 is an optionally substituted, partially saturated, fully saturated or fully unsaturated monocyclic, bicyclic or tricyclic ring optionally having 1 or more heteroatoms; and Q is an alkylene spacer that may include an optionally substituted aromatic ring optionally having 1 or 2 heteroatoms and/or another heteroatom containing moiety, such as O, S, SO, SO2, aminosulfonyl-, sulfonylamino, etc; and Z is -COOH or alkoxycarbonyl; methods of using such compounds, pharmaceutical compositions containing such compounds and kits containing such compounds. The compounds are useful as prostaglandin agonists and are useful for the treatment of bone disorders including osteoporosis.

L'invention concerne des agonistes de la prostaglandine, des procédés d'utilisation de ces agonistes ainsi que des compositions pharmaceutiques et des trousses contenant ces agonistes. Les agonistes de la prostaglandine permettent de traiter des troubles osseux ainsi que l'ostéoporose.

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