Method of preparing d-propoxyphene

Details Method of preparing d-propoxyphene Method of preparing d-propoxyphene

C - Chemistry, Metallurgy

07

C

C07C 213/06 (2006.01) C07C 219/22 (2006.01)

Patent

CA 2057866

D-propoxyphene can be prepared by reacting d-oxyphene and propionic anhydride. Preferably, an excess of propionic anhydride is used. The reaction easily proceeds at temperatures of l0 to 80 °C and produces yields exceeding 95 percent of theory. The free base d-propoxyphene can easily be converted in high yields to its hydrochloride or napsylate salts, both analgesics.

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