Pharmaceutical composition of hedgehog proteins and use thereof

Details Pharmaceutical composition of hedgehog proteins and use thereof Pharmaceutical composition of hedgehog proteins and use thereof

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 9/16 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 47/30 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 19/00 (2006.01) A61P 19/08 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 17/10 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2260423

A pharmaceutical composition of a hedgehog protein which is characterized in that the hedgehog protein is bound to a hydrophilic carrier that is biocompatible and biodegradable wherein the carrier is a polymer which - binds the hedgehog protein as a negatively-charged carrier as a result of ionic interactions, - does not denature the hedgehog protein when it binds to the carrier, - contains at least 0.1 to 2 negatively-charged residues per monomer under neutral conditions, - contains the charge in the form of acidic groups, - has an average molecular weight of at least 50,000 Da - and contains no agarose reversibly and actively releases hedgehog proteins in vivo from a carrier in a delayed manner.

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