Antimicrobial peptides and methods of use thereof

Details Antimicrobial peptides and methods of use thereof Antimicrobial peptides and methods of use thereof

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61P 31/00 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2412531

A class of cationic, polyphemusin-like peptides having antimicrobial activity is provided. Examples of such peptides include FRWCFRVCYKGRCRYKCR (SEQ ID NO:3), RRWCFRVCYKGFCRYKCR (SEQ ID NO:4), and RRWCFRVCYRGRFCYRKCR (SEQ ID NO:11). Also provided are methods for inhibiting the growth of microbes such as bacteria, yeast and viruses utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.

L'invention concerne une catégorie de peptides semblables à la polyphémusine cationiques, ces peptides possédant une activité antimicrobienne. Des exemples de ces peptides comportent FRWCFRVCYKGRCRYKCR (SEQ ID NO:3), RRWCFRVCYKGFCRYKCR (SEQ ID NO:4), et RRWCFRVCYRGRFCYRKCR (SEQ ID NO:11). L'invention concerne également des procédés d'inhibition de la croissance de microbes comme des bactéries, de la levure et des virus grâce aux peptides de la présente invention. Ces peptides servent en particulier à prévenir l'endotoxémie chez un sujet.

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