Protease activated receptor 2 variants

Details Protease activated receptor 2 variants Protease activated receptor 2 variants

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2370272

A variant PAR-2 receptor polypeptide or a fragment thereof is provided which (i) has reduced sensitivity to trypsin as compared with wild type PAR-2; (ii) has increased sensitivity to trans-cinnamoyl-LIGRLO-NH2 as compared with wild type PAR-2; and (iii) is activated by TLIGRL-NH2, which polypeptide or fragment thereof comprises an extracellular loop 2 (ECL-2) having at least one amino acid difference from the corresponding ECL-2 amino acid sequence of the wild type polypeptide.

On décrit un polypeptide récepteur PAR-2 variant ou un fragment de ce dernier qui: (i) présente une sensibilité réduite à la trypsine comparativement à PAR-2 de type sauvage; (ii) présente une sensibilité accrue au trans-cinnamoyl-LIGRLO-NH¿2? comparativement à PAR-2 de type sauvage; et (iii) est activé par TLIGRL-NH¿2?. Ce polypeptide ou ce fragment de polypeptide comprend une boucle extracellulaire 2 (ECL-2) ayant au moins une différence d'acide aminé avec la séquence d'acides aminés ECL-2 du polypeptide de type sauvage.

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