Method for diagnosing an adenocarcinoma or a benign prostate...

Details Method for diagnosing an adenocarcinoma or a benign prostate... Method for diagnosing an adenocarcinoma or a benign prostate...

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2336174

The invention concerns a method for diagnosing a prostate adenocarcinoma in a male human patient without performing prostatic biopsy, using the PSA protein (prostate specific antigen) present in the patient's blood, serum, urine or seminal liquid. The method consists in: a) measuring the free PSA total level, that is cleaved or non-cleaved; b) measuring the level of all or part of the cleaved free PSA; c) calculating the proportion of cleaved free PSA relative to the total free PSA; and d) diagnosing that the patient suffers from: a prostate adenocarcinoma, when said ratio is not more than a reference value; a benign prostate pathology, such as benign prostatic hypretrophy, when said ratio is higher than the reference value. It is also possible to calculate the proportion of non-cleaved free PSA relative to the free PSA total or the proportion of cleaved free PSA relative to the non-cleaved free PSA or to the total PSA or to the complexed PSA or to establish a ratio between those proportions. The invention is applicable to diagnosis of adenocarcinoma or benign prostatic hypertrophy.

La présente invention concerne une méthode de diagnostic d'un adénocarcinome de la prostate chez un patient humain mâle, sans pratiquer de biopsie prostatique, qui utilise la protéine PSA (prostate specific antigen) présente dans le sang, le sérum, l'urine ou le liquide séminal du patient. Elle consiste à: (a) mesurer le niveau de PSA libre total, c'est-à-dire clivé ou non clivé, (b) mesurer le niveau de tout ou partie du PSA libre clivé, (c) calculer la proportion de PSA libre clivé par rapport au PSA libre total, et (d) diagnostiquer que le patient est: atteint d'un adénocarcinome de la prostate, lorsque ce rapport est inférieur ou égal à une valeur de référence, ou atteint d'une pathologie bénigne de la prostate, telle qu'une hypertrophie bénigne de la prostate, lorsque ce rapport est supérieur à la valeur de référence. Il est également possible de calculer la proportion de PSA libre non clivé par rapport au PSA libre total ou la proportion de PSA libre clivé par rapport au PSA libre non clivé ou au PSA total ou au PSA complexé ou d'effecteur un ratio entre ces proportions. L'invention est appliquée au diagnostic de l'adénocarcinome ou de l'hypertrophie bénigne de la prostate.

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