A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/34 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2465476
The invention provides methods for establishing electrical coupling between cardiomyocytes and recombinant cells which have been genetically engineered to express a connexin protein such as connexin 43 (Cx43) protein. The invention is based on the discovery that genetic modification of skeletal muscle cells to express a recombinant connexin, enables the genetically modified cells to establish electrocommunication with cardiac cells via gap junctions. The recombinant connexin-expressing cells can be used for repair of cardiac tissue and for treatment of cardiac disease by transplantation into cardiac tissue.
L'invention concerne des méthodes d'établissement d'un couplage électrique entre des cardiomyocites et des cellules recombinées ayant été manipulées génétiquement pour exprimer une connexine telle que la connexine 43 (Cx43). L'invention repose sur la découverte selon laquelle le fait de modifier génétiquement les cellules des muscles squelettiques pour exprimer une connexine recombinée permet à ces dernières d'établir une électrocommunication avec les cellules cardiaques au moyen des jonctions lacunaires. On peut ainsi utiliser les cellules d'expression de la connexine pour réparer les tissus cardiaques et pour traiter les maladies cardiaques en greffant ces cellules dans le tissu cardiaque.
Fetherstonhaugh & Co.
The Regents Of The University Of California
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