C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 251/54 (2006.01) A61K 31/53 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2652040
Provided are methods of inhibiting prostaglandin transporter (PGT) activity in mammals. Also provided are methods of determining whether a test compound is an inhibitor of a prostaglandin transporter. Additionally provided are compounds that inhibit prostaglandin transporter activity, and pharmaceutical compositions of those compounds. Methods of inhibiting COX-2 in a mammal are also provided. Additionally, methods of treating pain or inflammation in a mammal are provided.
La présente invention concerne des procédés permettant d'inhiber l'activité du transporteur de la prostaglandine (PGT) chez des mammifères. L'invention concerne également des procédés permettant de déterminer si un composé d'essai est un inhibiteur d'un transporteur de la prostaglandine. Elle concerne de plus des composés qui inhibent l'activité du transporteur de la prostaglandine et des compositions pharmaceutiques desdits composés. L'invention concerne également des procédés permettant d'inhiber la COX-2 chez un mammifère ainsi que des procédés de traitement de la douleur ou de l'inflammation chez un mammifère.
Chang Young-Tae
Chi Yuling
Min Jaeki
Schuster Victor L.
Albert Einstein College Of Medecine Of Yeshiva University
New York University
Osler Hoskin & Harcourt Llp
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