Modified byrodin 1 with reduced immunogenicity

Details Modified byrodin 1 with reduced immunogenicity Modified byrodin 1 with reduced immunogenicity

C - Chemistry, Metallurgy

12

N

C12N 15/29 (2006.01) A61K 38/14 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 37/02 (2006.01) C07K 14/415 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2489153

The invention relates to the modification of bryodin 1 to result in bryodin 1 proteins that are substantially non~immunogenic or less immunogenic than any non-modified counterpart when used in vivo. The invention relates furthermore to T-cell epitope peptides derived from said non~modified protein by means of which it is possible to create modified bryodin 1 variants with reduced immunogenicity.

L'invention concerne la modification de bryodine 1 en protéines de bryodine 1 sensiblement non immunogènes ou moins immunogènes in vivo que leur contrepartie non modifiée. Elle concerne aussi des peptides d'épitope de lymphocyte T dérivés de cette protéine non modifiée au moyen desquels il est possible de créer des variants de bryodine 1 modifiée à immunogénicité réduite.

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