System for solid phase reactions

B - Operations – Transporting – 01 – J

Patent

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Details

B01J 19/28 (2006.01) B01D 15/02 (2006.01) B01D 15/08 (2006.01) B01J 19/00 (2006.01) C07K 1/04 (2006.01) C12M 1/40 (2006.01)

Patent

CA 2116360

2116360 9304756 PCTABS00020 A rotating processor (10) is disclosed. The apparatus (10) includes a hollow enclosed rotor (12), a rotor drive (104), internal space (24) to hold particulate porous reaction or separations media which may be porous, lines (40) connecting the center and periphera of the internal space with the exterior the through fluid line seals, valuing to control fluid flow, gradient makers, and a microprocessor to control and monitor the entire system. Optionally the rotor (12) may be spun with the axis vertical or horizontal, and may be used as a conventional column at rest. The rotating processor (10) permits any synthetic or separative process utilizing particulate or solid phase supports, or separations involving phases of different density to be accomplished under conditions which facilitate precise control of fluid flow and minimization of both micro- and macro-anomalous flow. A computer-controlled flat multiport valve system is also described to facilitate programmed scheduling of reagents through the rotor (12). Also disclosed are a process of synthesizing a polymer using the rotor (12) and a process of separating molecules using the processor (10).

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