Prodrugs of cgrp receptor antagonist

Details Prodrugs of cgrp receptor antagonist Prodrugs of cgrp receptor antagonist

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) A61K 31/675 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2722536

Disclosed are prodrug compounds of formula (I) (wherein variables R1 and R2 are as described herein) which are analogues of an antagonist of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

L'invention porte sur des composés de promédicaments représentés par la formule (I) (dans laquelle les variables R1 et R2 sont telles que décrites présentement) qui sont des analogues d'un antagoniste des récepteurs du CGRP et qui sutilisent dans le traitement ou la prévention de maladies dans lesquelles le CGRP est impliqué, telles que la migraine. L'invention porte également sur des compositions pharmaceutiques comportant ces composés et sur l'utilisation de ces composés et compositions dans la prévention ou le traitement de telles maladies dans lesquelles le CGRP est impliqué.

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