Methods for the treatment of dementia based on apo e genotype

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 31/27 (2006.01)

Patent

CA 2494585

This invention relates to methods to prevent worsening of and/or to improve cognitive functioning and behaviour problems in patients with dementia by means of ApoE genotyping to guide the use of AChEI drugs, including rivastigmine. Also included are kits for determining ApoE4 status and recommended treatment strategy.

L'invention concerne des méthodes permettant de prévenir la dégradation des fonctions cognitives et des problèmes de comportement et/ou d'améliorer ceux-ci chez des patients souffrant de démence, au moyen d'un génotypage de l'ApoE, aux fins de guidage de l'utilisation de médicaments contre l'AchEI, notamment la rivastigmine. L'invention concerne également des kits permettant de déterminer l'état de l'ApoE4 et une stratégie de traitement recommandée.

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