Dihydrobenzodiazepin-2-one derivatives iii

C - Chemistry – Metallurgy – 07 – D

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C07D 401/10 (2006.01) A61K 31/5513 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2474219

This invention relates to dihydro-benzo [b] [1, 4] diazepin-2-one derivatives of the general formula: (Formula I); wherein R1, R2, X and Y are as defined in the specification and R3 is a six-membered aromatic heterocycle containing 1 to 3 nitrogen atoms or a pyridine-N-oxide as further defined in the specification. The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurological disorders.

Cette invention porte sur des dérivés de dihydro-benzo [b] [1, 4] diazépine-2-one de formule générale (I) dans laquelle R?1¿, R?2¿, X et Y sont tels que définis dans le descriptif et R?3¿ est un hétérocycle aromatique à six éléments contenant 1 à 3 atomes d'azote ou un pyridine-N-oxyde également tels que défini dans le descriptif. L'invention porte en outre sur des médicaments contenant ces composés, sur leur procédé de préparation, ainsi que sur leur utilisation dans la préparation de médicaments visant à traiter ou prévenir les troubles neurologiques aigus et/ou chroniques.

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