Novel 2-(piperazin-1-yl)- and 2-([1,4]diazepan-1-yl)-...

Details Novel 2-(piperazin-1-yl)- and 2-([1,4]diazepan-1-yl)-... Novel 2-(piperazin-1-yl)- and 2-([1,4]diazepan-1-yl)-...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2543074

The invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula (I), in which R1 to R3 and n are as defined in claims 1 to 8, the tautomers, enantiomers, diastereomers, mixtures and salts thereof which have useful pharmacological properties, in particular, an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

L'invention concerne des imidazo[4,5-d]pyridazin-4-ones substituées de formule générale (I), dans laquelle R1 à R3 et n sont tels que définis dans les revendications 1 à 8, leurs tautomères, leurs énantiomères, leurs diastéréo-isomères, leurs mélanges et leurs sels, l'ensemble de ces composés présentant des propriétés pharmacologiques précieuses, en particulier, une action inhibitrice envers l'activité de l'enzyme dipeptidylpeptidase-IV (DPP-IV).

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