Phosphate derivatives of pharmaceutical products

A - Human Necessities – 61 – K

Patent

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Details

A61K 33/42 (2006.01) A61P 5/00 (2006.01) A61P 23/00 (2006.01) A61P 25/04 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2521842

According to the invention, there is provided a complex of a pharmaceutical compound selected from the group consisting of opioids, hormones, anaethetics and chemotherapeutic agents comprising the reaction product of: (a) one or more phosphate derivatives of one or more opioids, steroid hormones, thyroid hormones, anaesthetics or chemotherapeutic agents having a phenolic, primary alcohol, secondary alcohol or tertiary hydroxyl group; and (b) a complexing agent selected from the group comprising amphoteric surfactants, cationic surfactants, amino acids having nitrogen functional groups and proteins rich in these amino acids.

L~invention concerne un complexe d~un composé pharmaceutique sélectionné dans le groupe constitué par des opoïdes, des hormones, des substances anesthésiques ou chimiothérapeutiques comprenant le produit réactionnel de : a) un ou plusieurs dérivés phosphatés d~un ou de plusieurs opoïdes, hormones stéroïdes. Hormones thyroïdiennes, substances anesthésiques ou chimiothérapeutiques présentant un groupe phénolique, un groupe d~alcools primaires, un groupe d~alcools secondaires ou un groupe hydroxyle tertiaire ; et b) un agent complexant sélectionné dans le groupe constitué par des tensioactifs amphotères, des tensioactifs cationiques, des acides aminés présentant des groupes fonctionnels d~azote et des protéines riches de ces acides aminés.

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