C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/203 (2006.01) C07H 15/26 (2006.01) C07H 17/02 (2006.01) C07H 17/075 (2006.01) C12Q 1/34 (2006.01)
Patent
CA 2311387
The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidases take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
L'invention concerne des matériaux et des procédés permettant la conception, la synthèse et l'évaluation biochimique de composés de substrat chromogène dans le cadre des sialidases d'origine bactérienne, virale, protozoaire et vertébrée (y compris les êtres humains). L'invention concerne plus particulièrement une nouvelle classe de composés efficaces en tant que substrats chromogènes de ces sialidases qui génèrent des produits chromogènes après qu'ont eu lieu des réactions catalysées par sialidase. Font aussi l'objet de cette invention des procédés de préparation de ces composés de substrat, des techniques de diagnostic et pronostic des maladies associées à la sialidase utilisant ces composés de substrat.
Johnson Stephen C.
Luo Ming
Saeed Ashraf
Ibbex Inc.
Macrae & Co.
Uab Research Foundation
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