Pyridine carboxylic acid derivatives as glucokinase modulators

Details Pyridine carboxylic acid derivatives as glucokinase modulators Pyridine carboxylic acid derivatives as glucokinase modulators

C - Chemistry, Metallurgy

07

D

C07D 213/80 (2006.01) A61K 31/44 (2006.01) A61K 31/443 (2006.01) A61P 3/10 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2543643

A compound of Formula (I): wherein: A is phenyl or a 5- or 6-membered heteroaryl ring, optionally substituted; R1 and R2 are selected from hydrogen and methyl; with the proviso that at least one of R1 and R2 is methyl; or a salt, pro-drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

La présente invention a trait à un composé de formule (I), dans laquelle : A est phényle ou un noyau hétéroaryle à 5 ou 6 chaînons, éventuellement substitué ; R?1¿ et R?2¿ sont choisis parmi hydrogène et méthyle, à condition qu'au moins un parmi R?1¿ ou R?2¿ soit méthyle, ou un sel, prodrogue ou solvate de celui-ci. L'invention a également trait à des activateurs de la glucokinase, des compositions pharmaceutiques les contenant, et leurs procédés de préparation.

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