Human cns receptor polynucleotides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2179208

Human CNS receptor-encoding DNA is provided from which more than one form of the receptor protein, an edited form and an unedited form, is expressed in vivo. The edited and unedited receptor forms are functionally distinct, and appear to be selectively expressed. Thus, a CNS receptor-encoding gene that is subject to such editing has value in screening compounds for potential therapeutic utility.

Cette invention se rapporte à un ADN codant des récepteurs du système nerveux central (SNC) humain, ADN à partir duquel sont exprimées <u>in vivo</u> plus d'une forme de la protéine récepteur, une forme ayant subi l'édition et une forme n'ayant pas subi l'édition. La forme du récepteur ayant subi l'édition et la forme du récepteur n'ayant pas subi l'édition sont fonctionnellement distinctes et elles apparaissent comme ayant été exprimées sélectivement. Ainsi, un gène codant des récepteurs du SNC, qui est soumis à l'édition, peut servir pour trier des composés potentiellement utiles du point de vue thérapeutique.

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