Process for the preparation of an indole derivative

Details Process for the preparation of an indole derivative Process for the preparation of an indole derivative

C - Chemistry, Metallurgy

07

D

C07D 209/43 (2006.01) C07D 209/42 (2006.01)

Patent

CA 2128153

Abstract The invention relates to a new process for the preparation of 3-(3-carboxypropyl)-5-methoxyindole-2- carboxylic acid (I), characterized in that 6-carboethoxy- 6-p-methoxyphenylhydrazonohexanoic acid (II) is cyclized using a carboxylic acid which contains 1-3 carbon atoms, the resulting mixture comprising I, the two I monoethyl esters and I diethyl ester is treated with a strong inorganic base, and the resulting salt is converted into the free acid I by treatment with a strong acid.

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