Topical compositions for prostaglandin e1 delivery

Details Topical compositions for prostaglandin e1 delivery Topical compositions for prostaglandin e1 delivery

A - Human Necessities

61

K

A61K 31/5575 (2006.01) A61K 9/06 (2006.01) A61K 47/10 (2006.01) A61K 47/18 (2006.01) A61K 47/36 (2006.01) A61P 15/00 (2006.01) A61P 17/02 (2006.01) A61K 9/00 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2442479

A topical composition of a semi-solid consistency suitable is provided for transdermal application of prostaglandin E1. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer :is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)- alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.

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