Cyclohexylamin isoquinolone derivatives as rho-kinase...

Details Cyclohexylamin isoquinolone derivatives as rho-kinase... Cyclohexylamin isoquinolone derivatives as rho-kinase...

C - Chemistry, Metallurgy

07

D

C07D 217/24 (2006.01) A61K 31/472 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2615663

The invention relates to 6-cyclohexylamine-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I~) useful for the treatment and/or prevention of diseases associated with Rho- kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

L'invention concerne des dérivés de l~isoquinolone de formule (I) ou des dérivés de l~isoquinoline de formule (l') substitués en 6-cyclohexylamine, utiles pour la prévention et/ou le traitement de maladies associées à la Rho-kinase et/ou à la phosphorylation de la phosphatase à chaîne légère de la myosine par l~intermédiaire de la Rho-kinase, et des compositions qui contiennent de tel composants.

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