Diagnosis of mental disorders

Details Diagnosis of mental disorders Diagnosis of mental disorders

G - Physics

01

N

G01N 33/564 (2006.01) G01N 33/543 (2006.01) G01N 33/563 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2175697

There is described an assay for the diagnosis of a mental disorder in an individual. A blood sample, a platelet-containing fraction thereof, or a fraction containing platelet-associated antobodies (PAA) shed from the platelets is withdrawn from the individual to be diagnosed. The withdrawn sample is contacted with an anti-human immunoglobulin antibody lacking the Fc domain (Fc-less anti-hIg antibody) and the degree of binding thereof to the PAA is determined. A degree of binding above that found in normal individuals indicates that diagnosed individual has a high likelihood of having a mental disorder.

Dosage destiné au diagnostic de troubles mentaux chez un patient. Un échantillon de sang, une fraction dudit échantillon contenant des plaquettes ou une fraction contenant des anticorps associés aux plaquettes (PAA) séparés desdites plaquettes sont prélevés chez un patient pour lequel un diagnostic est à poser. L'échantillon prélevé est mis en contact avec un anticorps anti-immunoglobuline humaine auquel il manque le domaine Fc (anticorps anti-hIg moins Fc) et on détermine le degré de liaison dudit anticorps aux PAA. Un degré de liaison supérieur à celui trouvé chez des individus normaux indique qu'il y a une forte éventualité que le patient sur lequel a porté le diagnostic présente un trouble mental.

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