Use of tyrosine kinase inhibitors for treating inflammatory...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/00 (2006.01) A61K 31/015 (2006.01) A61K 31/095 (2006.01) A61K 31/40 (2006.01) A61K 31/403 (2006.01) A61K 31/404 (2006.01) A61K 31/415 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61K 31/498 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/66 (2006.01) A61K 45/06 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2452392

The present invention relates to a method for treating inflammatory bowel diseases (IBD), such as crohn's disease, comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non- toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor is unable to promotedeath of IL-3 dependent cells cultured in presence of IL-3.

La présente invention concerne une méthode de traitement des maladies intestinales inflammatoires (MII), telles que la maladie de Crohn, qui consiste à administrer, à un patient humain nécessitant un tel traitement, un inhibiteur de tyrosine kinase et plus spécifiquement un inhibiteur c-kit non toxique, sélectif et puissant. De préférence, ledit inhibiteur est incapable de favoriser la mort de cellules dépendant de IL-3 cultivées en présence de IL-3.

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