Ctla4 mutant molecules and uses thereof

Details Ctla4 mutant molecules and uses thereof Ctla4 mutant molecules and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2181394

The invention provides CTLA4 mutant molecules as ligands for the B7 antigen. Methods are provided for expressing CTLA4 mutant molecules as soluble, functional molecules, for preparing CTLA4 mutant fusion proteins, and for using these soluble molecules to regulate T cell interactions and immune responses mediated by such interactions.

L'invention porte sur des molécules CTLA4 mutantes utilisées comme ligands de l'antigène B7. Sont divulguées des méthodes permettant d'exprimer des molécules CTLA4 mutantes solubles et fonctionnelles dans le but de préparer des protéines de fusion CTLA4 mutantes et d'utiliser ces molécules solubles afin de réguler les interactions des lymphocytes T et les réponses immunitaires dans lesquelles ces interactions jouent un rôle.

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