Carbonic anhydrase inhibitors derivatives

Details Carbonic anhydrase inhibitors derivatives Carbonic anhydrase inhibitors derivatives

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/38 (2006.01) A61K 31/542 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2671137

Nitroderivatives of dorzolamide and brinzolamide having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma, ocular hypertension, age-related macular degeneration, diabetic macular edema, diabetic retinopathy, hypertensive retinopathy and retinal vasculopathies.

La présente invention concerne des dérivés nitrés de dorzolamide et de brinzolamide qui présentent une activité pharmacologique améliorée et qui sont mieux tolérés. Lesdits dérivés peuvent être utilisés pour le traitement du glaucome, de l'hypertension oculaire, de la dégénérescence maculaire liée à l'âge, de l'AEdème maculaire diabétique, de la rétinopathie diabétique, de la rétinopathie hypertensive et des vasculopathies rétiniennes.

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