Process for purifying glycopeptide phosphonate derivatives

Details Process for purifying glycopeptide phosphonate derivatives Process for purifying glycopeptide phosphonate derivatives

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) C07K 1/14 (2006.01)

Patent

CA 2457218

Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods include contacting a solution of the glycopeptide derivatives with a polystyrene-containing resin, eluting the resin with an aqueous solution, and isolating the purified glycopeptide derivative.

La présente invention concerne des procédés de purification de glycopeptides qui sont substitués par un ou plusieurs substituants comprenant chacun un ou plusieurs groupes phosphono et qui sont utiles en tant qu'agents antibactériens. Les procédés consistent à mettre en contact une solution des dérivés de glycopeptides avec une résine contenant du polystyrène, à éluer la résine avec une solution aqueuse et à isoler le dérivé de glycopeptide purifié.

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