C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/18 (2006.01) C07K 16/26 (2006.01) C12N 15/16 (2006.01) C12N 15/63 (2006.01) C12Q 1/00 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2316280
The present invention is directed to novel G protein-coupled receptors that are found predominantly in the dorsal root ganglia. The invention encompasses both receptor proteins as well as nucleic acids encoding the proteins. Angiotension I and III effects Calcium signalling in Cells transformed with DNA encoding the receptor. In addition, the present invention is directed to methods and compositions which utilize the receptors.
L'invention concerne de nouveaux récepteurs associés à la protéine G, qu'on trouve principalement dans les ganglions spinaux. L'invention concerne les protéines réceptrices ainsi que les acides nucléiques codant pour ces protéines. Les angiotensines I et III provoquent une signalisation du calcium dans les cellules transformées par un ADN codant pour ce récepteur. L'invention concerne en outre des procédés et des compositions comprenant ces récepteurs.
Ahmad Sultan
Banville Denis
Fortin Yves
Lembo Paola
O'donell Dajan
Astrazeneca Canada Inc.
Fetherstonhaugh & Co.
National Research Council Of Canada
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