A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/18 (2006.01) A01N 1/02 (2006.01) A61K 47/22 (2006.01) C12N 1/04 (2006.01)
Patent
CA 2162305
In comparison with currently used methods for storing blood, the following advantages could be achieved by the addition according to the invention of D,L-.alpha.-lipoic acid and/or the enantiomers thereof and/or the derivatives thereof before storage: the properties of erythrocyte concentrates at 4°C could be improved with regard to their oxygen release capacity (2,3-DPG) and viscoelasticity and with regard to membrane peroxidation during storage and for subsequent transfusion by means of the above-stated bodily, i.e. physiological substance. The same applies to cryogenically stored erythrocytes which are additionally protected from damage by the freeze/thaw process and the erythrocyte aggregability of which is improved.
En comparaison avec les méthodes actuellement utilisées pour conserver du sang, il est possible d'obtenir les avantages suivants par l'addition, selon l'invention, d'acide D, L-.alpha.-lipoïque et/ou leurs énantiomères et/ou leurs dérivés avant le stockage : les propriétés des concentrés érythrocytaires à 4°C pourraient être améliorées en ce qui concerne leur capacité de libérer de l'oxygène (2,3-DPG) et la viscoélasticité et en ce qui concerne la peroxydation des membranes pendant le stockage et pour une transfusion ultérieure au moyen de la substance corporelle, c.-à- d. physiologique susmentionnée. Cela s'applique également aux érythrocytes cryogéniquement conservés qui sont en outre protégés contre les dommages causés par le processus de gel/dégel et dont l'agrégabilité érythrocytaire est amélioré.
Conrad Frank
Geise Wolfgang
Henrich Hermann-August
Ulrich Heinz
Asta Medica Aktiengesellschaft
Evonik Degussa Gmbh
Marks & Clerk
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