Imidazopyridine paf/h _antagonists

Details Imidazopyridine paf/h _antagonists Imidazopyridine paf/h _antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/445 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2099381

Compounds of formula (I), wherein X is CH or N; Z is CH=CH or S; A is CH2CH2, CH=CH, CH(OH)CH2, or COCH2; B is a direct link or -CH2-, -CH(CH3)- or -C(CH3)2-, or when Z is CH=CH, B may form a cyclopentane ring fused to the attached benzene ring; Y completes a fused benzo or thienyl ring which is optionally substituted by halo or C1-C4 alkyl; n is 0, 1 or 2; and m is 0 or 1; are antagonists of both PAF and histamine H1 having utility in the treatment of allergic inflammatory conditions such as allergic rhinitis.

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