Substituted biaryl analogues

Details Substituted biaryl analogues Substituted biaryl analogues

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/44 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) A61P 11/06 (2006.01) A61P 13/10 (2006.01) A61P 25/06 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01)

Patent

CA 2590586

Substituted biaryl analogues of Formula (I) are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localizations studies.

L'invention concerne des analogues de biaryle substitués de formule (I) . De tels composés sont des ligands pouvant être utilisés pour moduler l'activité d'un récepteur spécifique in vivoou in vitro, et en particulier ces composés sont utiles pour traiter des troubles associés à une activation de récepteurs pathologique, chez des humains, chez des animaux domestiques et chez des animaux d'élevage. L'invention concerne des compositions pharmaceutiques et des méthodes d'utilisation de tels composés pour traiter de tels troubles, ainsi que des méthodes pour utiliser de tels ligands destinés à des études de localisation de récepteurs.

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