N-acylpiperidinylcarbonylaminocarboxylic acids and their use...

Details N-acylpiperidinylcarbonylaminocarboxylic acids and their use... N-acylpiperidinylcarbonylaminocarboxylic acids and their use...

C - Chemistry, Metallurgy

07

D

C07D 211/60 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/695 (2006.01) C07D 211/36 (2006.01) C07D 217/26 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 411/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2215106

This invention relates to .beta.-alanine derivatives represented by formula (Ia) wherein each symbol is as defined in the specification and pharmaceutically acceptable salt thereof which is glycoprotein IIB/IIIa antagonist, inhibitor of blood platelets aggregation and inhibitor of the binding of fibrinogen to blood platelets, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.

L'invention concerne des dérivée de .beta.-alanine représentés par la formule (Ia), dans laquelle chaque symbole est comme défini dans les spécifications, ainsi qu'un sel pharmaceutiquement acceptable de ceux-ci qui est un antagoniste de la glycoprotéine IIB/IIIa, un inhibiteur de l'agrégation plaquettaire et un inhibiteur de la fixation du fibrinogène aux plaquettes sanguines. L'invention porte également sur des procédés de préparation desdits dérivés, une préparation pharmaceutique les contenant et une méthode de prévention et/ou de traitement, chez l'animal ou l'humain, des maladies citées dans les spécifications.

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