Vasoconstriction compositions and methods of use

Details Vasoconstriction compositions and methods of use Vasoconstriction compositions and methods of use

A - Human Necessities

61

K

A61K 31/498 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2732521

The invention generally relates to topical and aerosolized compositions for inducing vasoconstriction with low incidence of rebound hyperemia The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume The compositions preferably comprise brimonidine The compositions preferably have pH between about 5.5 and about 6.5.

L'invention concerne de manière générale des compositions topiques et sous forme d'aérosol pour induire une vasoconstriction avec une incidence faible d'hyperémie réactionnelle. Les compositions comprennent des agonistes du récepteur adrénergique alpha-2 sélectif, à des faibles concentrations, de moins de 0,05 % en poids par volume. Les compositions comprennent de préférence de la brimonidine. Les compositions ont de préférence un pH compris entre environ 5,5 et environ 6,5.

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