Morpholino pyrimidine derivatives used in diseases linked to...

Details Morpholino pyrimidine derivatives used in diseases linked to... Morpholino pyrimidine derivatives used in diseases linked to...

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2692720

A compound of formula (I) or a pharamaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of proliferative disease such as cancer and particularly in disease mediated by an mTOR kinase and/or one or more PI3K enzyme.

L'invention porte sur un composé de formule (I) ou un sel pharmaceutiquement acceptable de celui-ci, sur des procédés permettant de les préparer, sur des compositions pharmaceutiques les contenant et sur leur utilisation en thérapie, par exemple dans le traitement d'une maladie proliférative telle que le cancer et, en particulier, d'une maladie à médiation par une mTOR kinase et/ou une ou plusieurs enzymes PI3K.

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