Uses of notch related genes

Details Uses of notch related genes Uses of notch related genes

G - Physics

01

N

G01N 33/574 (2006.01) A61K 38/17 (2006.01) A61K 38/53 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2375325

The invention relates to the use of human homologues of Drosophila Suppressor of deltex (h-SDRP) in the form of nucleic acids, proteins and antibodies in diagnosis and therapy. The h-SDRP nucleic acid and amino acid sequences and antibodies thereto may be used according to the invention for the detection and quantitation of h-SDRP mRNA and protein, to study the expression thereof, to produce h-SDRP proteins, fragments and other derivatives or analogues for use in the study, assay and manipulation of differentiation and other physiological processes in which Drosophila Su(dx) is postulated to be involved, e.g. diseases of cell fate and abnormal differentiation and cell proliferation.

L'invention concerne l'utilisation d'homologues humains des suppresseurs de deltex (h-SDRP) de drosophile, sous la forme d'acides nucléiques, de protéines et d'anticorps, pour le diagnostic et la thérapie. D'après ladite invention, les séquences et anticorps d'acides nucléiques et d'acides aminés h-SDRP peuvent être utilisés pour la détection et la quantification d'ARNm et de protéine h-SDRP, afin d'étudier leur expression, de produire des protéines h-SDRP, des fragments et d'autres dérivés ou analogues pour l'utilisation dans l'étude, les tests et la manipulation de la différenciation et autres processus physiologiques, dans lesquels le Su(dx) peut être impliqué, par ex : les maladies de sort de cellule, la différenciation anormale, et la prolifération de cellules.

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