Amino-terminally truncated rantes as chemokine antagonists

Details Amino-terminally truncated rantes as chemokine antagonists Amino-terminally truncated rantes as chemokine antagonists

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 38/48 (2006.01) C07K 14/52 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2304827

The present invention relates to amino-terminally truncated RANTES, lacking NH2-terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3 or 1- 4 of the naturally-occurring RANTES and having chemokine antagonistic activity, as well as cDNA sequences encoding them, their use in therapy and/or in diagnosis of the diseases, in which an antagonistic activity of the chemokine effects is required, and pharmaceutical compositions comprising them.

La présente invention concerne des RANTES tronqués à acide aminé terminal, ne possédant pas les acides NH¿2?-aminés terminaux correspondant aux résidus d'acides aminés 1, 1-2, 1-3 ou 1-4 des RANTES naturels et présentant une activité antagoniste de la chémokine. L'invention concerne des séquences d'ADNc codant ces composés, leur utilisation pour traiter et/ou diagnostiquer les maladies, dans lesquelles il est nécessaire d'avoir une activité antagoniste des effets de la chémokine. L'invention concerne aussi des compositions pharmaceutiques comprenant ces composés.

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