3-substituted-1h-indole compounds, their use as mtor kinase...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 407/04 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2723279

The invention relates to 3-substituted-1H-indole compounds of the Formula (I): or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds for the treatment of PI3 and mTOR kinase- mediated diseases, e.g. cancer.

Cette invention concerne des composés de 1H-indole 3 substitués représentés par la formule 1, ou bien un sel de ces composés de qualité pharmaceutique. Elle concerne également les variables des constituants comme définies dans le descriptif, des compositions renfermant les composés et des procédés de fabrication de ces composés.

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