Novel synthesis of piperazine ring

Details Novel synthesis of piperazine ring Novel synthesis of piperazine ring

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01)

Patent

CA 2370389

A novel process for preparing a compound of formula (I) wherein R1 denotes substituted or unsubsituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy; R2 denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy, arylalkoxy, tosyl, formyl, acetyl or amine; and R3 denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy is disclosed. These compounds are useful in the synthesis of the antidepressant mirtazapine and other tetracyclic compounds.

L'invention se rapporte à un nouveau procédé de préparation d'un composé représenté par la formule (I), dans laquelle R?1¿ représente alkyle substitué ou non substitué, alkoxy, aryle, aryloxy ou arylalkoxy; R?2¿ représente alkyle substitué ou non substitué, alkoxy, aryle, aryloxy, arylalkoxy, tosyle, formyle, acétyle ou amine; et R?3¿ représente alkyle substitué ou non substitué, alkoxy, aryle, aryloxy ou arylalkoxy. Ces composés sont utiles pour la synthèse de la mirtazapine antidépressive et d'autres composés tétracycliques.

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