C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/70 (2006.01) C12N 15/81 (2006.01) C12N 15/85 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2354375
The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
La présente invention concerne des compositions et des procédés destinés au diagnostic et au traitement de la croissance et la prolifération des cellules néoplasiques chez les mammifères, y compris les humains. Cette invention repose sur l'identification du gène de cardiotrophine-1 amplifié dans le génome des cellules tumorales. Une telle amplification génique devrait s'associer à la surexpression du produit génique et contribuer à l'oncogenèse. De même, on pense que le polypeptide de cardiotrophine-1 codé par le gène amplifié représente une cible utile pour le diagnostic et/ou le traitement (y compris la prévention) de certains cancers, et peut agir comme signe précurseur pour le pronostic du traitement tumoral.
Botstein David
Goddard Audrey
Lawrence David A.
Pennica Diane
Roy Margaret Ann
Dennison Associates
Genentech Inc.
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